Absolutely you can get regkey information. Two methods, Mark Cochrane's RegKeyToMof to build your mof edits so you can extend hardware inventory and then you will have a custom view with that information Or, if you need just to know "if this regkey exists
and it is exactly this value, then that's a good thing, (compliant) if not, then that's a bad thing (non-compliant)", to me that is easier to do using DCM, desired configuration management.
Standardize. Simplify. Automate.